Platelet count and platelet function testing in acute coronary syndromes
نویسندگان
چکیده
منابع مشابه
Baseline platelet count and clinical outcome in acute coronary syndrome.
BACKGROUND It is unclear whether platelet count (PLT) is independently associated with clinical outcome in patients with acute coronary syndrome (ACS). METHODS AND RESULTS MEDLINE, EMBASE, the Cochrane library clinical trials registry, ISI Science Citation Index, and ISI Web of Knowledge were searched, supplemented by hand-scanning of references of relevant publications and contacting content...
متن کاملPlatelet count as a prognostic marker in patients with acute coronary syndromes.
latelets play important roles in the pathophysiological process of acute coronary syndromes (ACS). Platelet activation, aggregation and thrombus formation secondary to plaque disruption have been implicated as major pathogenic mechanisms underlying ACS. Moreover, activated platelets mediate inflammation through adhesive interaction with leukocytes and endothelial cells, secretion of vasoactive ...
متن کاملPlatelet glycoprotein IIb/IIIa inhibition in acute coronary syndromes.
Acute coronary syndromes are a leading cause of hospitalization in industrialized countries. Current antithrombotic therapy focuses on relatively weak antiplatelet agents and heparin. The advent of inhibitors of the platelet glycoprotein IIb/IIIa receptor, the final common pathway for aggregation, provides a new therapeutic modality. Clinical trials with a total of more than 18,000 patients hav...
متن کاملIncreased platelet binding to circulating monocytes in acute coronary syndromes.
BACKGROUND Present therapies for acute coronary syndromes aim toward limiting platelet-platelet adhesion and aggregation processes. However, platelet-leukocyte interactions may contribute importantly to disease progression in the arterial wall. Recent studies suggest that prevention of platelet-leukocyte binding via P-selectin glycoprotein ligand-1 (PSGL-1) may be beneficial in animal models of...
متن کاملBiomarkers of platelet activation in acute coronary syndromes.
The most convincing evidence for the participation of platelets in arterial thrombosis in humans comes from studies of platelet activation in patients with acute coronary syndromes (ACS) and from trials of antiplatelet drugs. Both strongly support the concept that repeated episodes of platelet activation over the thrombogenic surface of a vulnerable plaque may contribute to the risk of death fr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Heart, Lung and Circulation
سال: 2014
ISSN: 1443-9506
DOI: 10.1016/j.hlc.2014.04.069